In House Study
Protective Study of Phyllanthus niruri Conducted in Our Laboratories.
Tilte: Liver protective
activity of Phyllanthus niruri standardized extract against paracetamol
induced liver injury in mice.
oxidised into paracetemol radical in the liver tissue by liver
enzyme, cytochrome P450. The free radical formed will cause liver
injury which is shown by elevated serum ALT and AST levels. Phyllanthus
protects the liver against injury by scavenging up the free radicals
formed. This study demonstrated that Phyllanthus possesses anti-oxidant
activity and liver protective effect.
Paracetemol was administrated by intraperitoneally injection into
rat to cause liver injury. The degree of liver injury was demonstrated
by the elevated serum ALT and AST levels. In the treated group,
HERPA-PTM capsule was given orally for 5 days before
the administration of paracetemol injection on the 6th day. Result
showed a significant difference between control and treatment
group in the elevation of serum ALT and AST levels. HERPA-PTM
capsule was shown to offer liver protection against paracetemol-induced
liver injury in mice.